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Bioinformatics Course 201

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Bioinformatics Course 201 is designed to delve deeper into the realms of genomic analysis, providing students with advanced knowledge and practical skills in bioinformatics. This course builds upon the foundational concepts introduced, focusing on Introduction to Bioinformatics, DNA sequence and its analysis, comparative genomics, whole genome alignment, and phylogenetics. Students will gain hands-on experience in utilizing cutting-edge bioinformatics tools and techniques to analyze genetic data across various organisms, including microbes, plants, animals, and humans. Key Topics: 1. Introduction to Bioinformatics: - Recap of fundamental concepts in bioinformatics - Overview of current trends and challenges in genomic analysis 2. DNA Sequencing and its Analysis: - Principles of DNA sequencing technologies (e.g., Sanger sequencing, next-generation sequencing) - Importing and Managing Sequence Data and Calling Complementary Strands - Identifying Codons and Translation into Proteins - Protein Coding Regions Identification, Open Reading Frame (ORF) Analysis and Primer Design 3. Hands-on Comparative Genomics: - Comparative analysis of genomes from different species - Identification of conserved regions and evolutionary changes - Exploration of gene families and functional annotation across species 4. Whole Genome Alignment: - Techniques for aligning entire genomes - Practical applications in identifying genomic rearrangements associated with diseases 5. Whole Genome Phylogenetics: - Principles of phylogenetic analysis and tree construction - Molecular evolution and phylogenetic inference methods - Phylogenetic applications in understanding evolutionary relationships and species divergence

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